Cost-utility analysis of lifestyle modification program for Thai patients with metabolic syndrome

Background Several foreign trials indicated clinical benefits and cost-effectiveness of the lifestyle programs for patients with metabolic syndrome (MetS) but the economic benefit of such programs has not yet been evaluated in Thailand. Objective This study was aimed to assess the cost-effectiveness of the lifestyle modification program for Thai MetS patients compared with the usual care. Design Secondary data analysis with modelling design. Setting Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University Methods A cost-utility analysis was performed based on Praphasil and colleagues’ study of 90 MetS patients randomly allocated to the lifestyle modification program and control groups. A Markov micro-simulation model with the Differences-in-Differences method was used to predict the lifetime costs from societal perspective and quality-adjusted life years (QALYs) from patients’ metabolic parameters. The 3% discount rate per annum was employed to discount the costs and outcomes. Parameter uncertainties were identified using a sensitivity analysis. นพินธต์น้ฉบบั